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KMID : 0380020130280010036
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Korean Journal of Biotechnology and Bioengineering
2013 Volume.28 No. 1 p.36 ~ p.41
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Evaluation of Antioxidant and Anti-Inflammatory Activities of Ascidian Tunic Carotenoids As a Source of Color Cosmetics
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Ticar Bernadeth
Rohmah Zuliyati
Bat-Erdene Munkhjagal
Park Si-Hyang
Choi Byeong-Dae
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Abstract
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Carotenoids are fat-soluble red-orange colored pigments found in plants and seafood-derived products, including algae, seaweeds, and fish muscle. In this study, we have demonstrated the molecular mechanism underlying the antioxidants and anti-inflammatory properties of ascidian tunic carotenoids using mouse macrophage cell line (RAW 264.7). Cell viability was not affected by treatment of carotenoids < 10 μg/mL. This treatment also showed negative inhibition on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) and cyclooxygenase-2 (COX-2). The DPPH radical scavenging activity of carotenoids was 47.2% at 100 mg/mL. It also has a potential reducing power (1.025) comparable with ascorbic acid (1.584). The ascidian tunic carotenoids would make a candidate for the commercially interesting biologically active cosmetic pigments.
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KEYWORD
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Ascidian tunic carotenoids, DPPH radical, color cosmetics, NO, COX-2
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